Oprah Winfrey led the charge for female empowerment at the Golden Globes when she delivered a powerful speech urging men and women to work together to ensure no one ever has to utter the words 'Me Too' again.

The actress and businesswoman, who received a lengthy standing ovation as she accepted the Cecil B. DeMille Award at Sunday's Globes ceremony, said she was honored to be the first black woman to receive the accolade.

The 63-year-old, who left most of the audience in tears, began her speech speaking about the feelings she had as a young girl watching Sidney Poitier win the best actor Academy Award in 1964.