Black Stars head coach Otto Addo can now name 26 players for the 2022 FIFA World Cup in Qatar.
Unlike the past where teams had to name 23 players, three more have now been allowed.
Fifa has approved 26-man squads for this year's World Cup in Qatar.
The move is in line with recent national competitions and is an expansion on the 23-man squads that had been used before the coronavirus pandemic.
Fifa also said up to 15 substitutes can be named for a game, meaning no player misses out.
The deadline for all 32 countries competing to submit their final squads is 20 October - 30 days before the first game between Senegal and the Netherlands at the Al Thumama Stadium.
Fifa also said that no more than 26 people - up to 15 substitutes and 11 team officials, of which one must be the team doctor - will be allowed to sit on the bench.
The Blacks Stars of Ghana qualified for their fourth ever World Cups after beating bitter rivals Nigeria vía the away goal rule after a two legged play off game.
Ghana is in group H alongside Portugal, Korea and Uruguay.