Louis Moult has scored five goals for Preston this season, including the equaliser in a 1-1 draw with Hull in OctoberFollow live text coverage from 14:00 GMT on Wednesday
Preston North End boss Alex Neil has a major quandary up front after Louis Moult joined a five-strong group of injured strikers.
Lukas Nmecha is the only regular fit striker, but Tom Barkhuizen could also operate in a forward area.
Hull City defender Ondrej Mazuch is Nigel Adkins' main concern after he was withdrawn at half-time in Saturday's 3-2 win against Swansea City.
The Czech international could again be replaced by Jordy de Wijs.
Match facts
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Preston North End are unbeaten in their last four meetings with Hull City, including a 1-1 draw earlier this season at the KC Stadium, thanks to a 90th minute equaliser from Louis Moult.
Jarrod Bowen has scored for Hull City in each of their last three competitive meetings with Preston North End - all three being the Tigers' only goal of that game.
This will be the first Boxing Day meeting between Preston and Hull for 90 years - in the 1928 meeting, Preston won 1-0.
Hull manager Nigel Adkins has lost his last three matches in all competitions at Deepdale against Preston, losing to three different managers - Alan Irvine in 2008, Darren Ferguson in 2010 and Alex Neil earlier this year.
Preston have lost just two of their last 16 home matches in all competitions (W8 D6).
Hull have won just two of their last 17 away league matches in December (D5 L10), with one of those wins coming on Boxing Day in 2014 at Sunderland.
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