Doctors have confirmed a diagnosis made more than 200 years ago by one of medicine's most influential surgeons.
John Hunter had diagnosed a patient in 1786 with a "tumour as hard as bone".
"It started out as a bit of fun exploration, but we were amazed by John Hunter's insight," Dr Christina Messiou told the BBC News website.
Mr Hunter became surgeon to King George III in 1776 and is one of the surgeons credited with moving the medical discipline from butchery to a science.
He's also rumoured to have given himself gonorrhoea as an experiment while writing a book about venereal diseases.
His huge medical collection is now housed at the Hunterian Museum at the Royal College of Surgeons.
It includes his colourful notes describing a man who arrived at St George's Hospital, in 1786, with a hard swelling on his lower thigh.
"It appeared to be a thickening of the bone, it was increasing very rapidly... On examining the diseased part, it was found to consist of a substance surrounding the lower part of the thigh bone, of the tumour kind, which seemed to originate from the bone itself."
Mr Hunter amputated the man's leg and he recovered briefly for four weeks.
"From this time he began to lose flesh and sink gradually, his breathing more and more difficult," the notes continued.
The patient died seven weeks after the operation and an autopsy discovered bony tumours had spread to his lungs, the lining of the heart and on the ribs.