The Black Stars have had their final training session as the match venue just as the Caf rules stipulate for away teams.
Ghana defeated closest challengers in the group South Africa by two goals to nil at the Cape Coast Stadium last Thursday and would want to add the African minnows to their scalp.
More especially after South Africa defeated Sudan by a lone goal to move level on points with the Black Stars having played a game more.
The match will be played at the Estadio Nacional 12 de Julho in São Tomé on Monday 18 November.
Kick off time is 13:00 Hours GMT.