Tony Pulis' Boro have failed to win any of their past four Championship gamesFollow live text coverage on Saturday on 14:00 GMT
Reading have Scott Marshall in caretaker charge for a third game in succession when they host Middlesbrough.
Goalkeeper Vito Mannone and striker Jon Dadi Bodvarsson are among a number of Royals players close to returning from injury.
Boro rested several first-teamers in Tuesday's Carabao Cup quarter-final loss to League One side Burton.
Britt Assombalonga and George Saville are among those hoping to return.
Reading have lost each of their last three league games against Middlesbrough, with the most recent two of those coming home (0-2) and away (1-2) last season.
Middlesbrough won 2-0 in this Championship fixture last season, while they've never previously won consecutive away league games against Reading.
Middlesbrough boss Tony Pulis has never won away at Reading in nine previous such meetings as a manager in all competitions (D3 L6), losing 3-1 in his most recent visit in the FA Cup as West Brom boss in February 2016.
Middlesbrough have fired in just 77 shots on target this season, only Hull (71), Bolton (58) and Ipswich (51) have registered fewer.
Reading are without a win in six games, although four of those have been draws (L2).
Reading have registered just one clean sheet in their last 13 home league games - 3-0 versus Hull in September.